Clinical Pharmacology Chapter 20 Opioid Analgesics Q&A (1 OF 26) Sample Questions

1. The antagonist of choice in the treatment of opioid over dosage is:
  1. A. Naloxone
  2. B. Nalorphine
  3. C. Pentazocine
  4. D. Methadone
  5. E. Clonidine
Answer
Ans: A
Tips: Misbah Pharmacology Review Book. Naloxone’s mechanism of action is full antagonism at mu receptors given as IV and nasal spray only because it undergoes extensive first-pass effect of 98%.